Cascade synthesis of pyrido[3,2-a]indolizines by reaction of Kröhnke–Mukaiyama salts with malononitrile dimer

dc.contributor.author	Tverdokhleb, N. M.
dc.contributor.author	Khoroshilov, G. E.
dc.contributor.author	Dotsenko, V. V.
dc.contributor.author	Твердохлеб, Н. М.
dc.contributor.author	Хорошилов, Г. Е.
dc.contributor.author	Дотсенко, В. В.
dc.date.accessioned	2018-06-23T21:20:48Z
dc.date.available	2018-06-23T21:20:48Z
dc.date.issued	2014
dc.identifier.uri	http://hdl.handle.net/123456789/2772
dc.description	Tverdokhleba N. M. Cascade synthesis of pyrido[3,2-a]indolizines by reaction of Kröhnke–Mukaiyama salts with malononitrile dimer / N. M.Tverdokhleba, G. E.Khoroshilova, V. V.Dotsenko // Tetrahedron Letters. - 2014. - Vol. 55 (26 November). - P. 6593-6595.	uk_UA
dc.description.abstract	An efficient protocol for the synthesis of highly functionalized 2-aminoindolizines and pyrido[3,2-a]indolizines has been achieved via the reaction of N-RC(O)CH2-2-chloropyridinium bromides with 2-amino-1,1,3-tricyanopropene in the presence of Et3N. The reaction of N-allyl-2-chloropyridinium bromide with 2-amino-1,1,3-tricyanopropene in the presence of Et3N gives 3-[1-allylpyridin-2(1Н)-ylidene]-2-aminoprop-1-ene-1,1,3-tricarbonitrile, which could be cyclized to give [2-amino-(2-amino-3-vinylindolizin-1-yl)methylene]malononitrile upon treatment with KOH–DMF.	uk_UA
dc.language.iso	other	uk_UA
dc.subject	хімічні науки	uk_UA
dc.title	Cascade synthesis of pyrido[3,2-a]indolizines by reaction of Kröhnke–Mukaiyama salts with malononitrile dimer	uk_UA
dc.type	Article	uk_UA