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Title: | Cascade synthesis of pyrido[3,2-a]indolizines by reaction of Kröhnke–Mukaiyama salts with malononitrile dimer |
Authors: | Tverdokhleb, N. M. Khoroshilov, G. E. Dotsenko, V. V. Твердохлеб, Н. М. Хорошилов, Г. Е. Дотсенко, В. В. |
Keywords: | хімічні науки |
Issue Date: | 2014 |
Abstract: | An efficient protocol for the synthesis of highly functionalized 2-aminoindolizines and pyrido[3,2-a]indolizines has been achieved via the reaction of N-RC(O)CH2-2-chloropyridinium bromides with 2-amino-1,1,3-tricyanopropene in the presence of Et3N. The reaction of N-allyl-2-chloropyridinium bromide with 2-amino-1,1,3-tricyanopropene in the presence of Et3N gives 3-[1-allylpyridin-2(1Н)-ylidene]-2-aminoprop-1-ene-1,1,3-tricarbonitrile, which could be cyclized to give [2-amino-(2-amino-3-vinylindolizin-1-yl)methylene]malononitrile upon treatment with KOH–DMF. |
Description: | Tverdokhleba N. M. Cascade synthesis of pyrido[3,2-a]indolizines by reaction of Kröhnke–Mukaiyama salts with malononitrile dimer / N. M.Tverdokhleba, G. E.Khoroshilova, V. V.Dotsenko // Tetrahedron Letters. - 2014. - Vol. 55 (26 November). - P. 6593-6595. |
URI: | http://hdl.handle.net/123456789/2772 |
Appears in Collections: | Статті |
Files in This Item:
File | Description | Size | Format | |
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Tetrahedron_Letters.pdf | 1.23 MB | Adobe PDF | View/Open |
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